Our Expertise in Pre-Clinical Research

Our pre-clinical services for skin and hair diseases have been designed to encompass the entire product development journey from low-cost investigative in vitro and ex vivo studies through to compound efficacy testing applied in in vivo humanized mouse models.

Our passion is to meet our clients’ expectations and to perform comprehensive testing of pharmaceutical, cosmeceutical or nutraceutical compounds for skin and hair disease management. Additionally, we aim at delivering new research solutions for qualified scientific claim substantiation of formulations developed to increase skin and hair health benefits.

As further advantage, we have access to healthy and diseased hair and skin samples which we regularly obtain from our great network of dermatologists and plastic surgeons. All collected samples are stored within the “Monasterium Laboratory Biobank”.

We offer state-of-the-art techniques, e.g. (single cell) RNAseq, laser capture microdissection, applied to healthy and diseased tissue samples and pre-clinical models to identify novel targets in skin and hair disorders that can be modulated by pharmaceutical, cosmeceutical or nutraceutical compounds.
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We offer state-of-the-art techniques, e.g. in situ hybridization, multiplex immunostainings, applied to healthy and diseased tissue samples and pre-clinical models to examine the source, expression and localization of your target of interest in healthy and diseased skin and hair samples.
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We offer pre-clinical models, and state-of-the-art techniques, including gene silencing ex vivo, to study if modulation of your target of interest provides an efficient therapeutic benefit on skin and hair pathology within an acceptable safety window.
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We offer pre-clinical models to identify the underlying molecular mechanisms in skin and hair samples addressed by your target.
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We offer pre-clinical models to examine the efficacy and safety of your compound on targets of interest in comparison to well known agents.
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We use pre-clinical models, including organ culture of diseased skin samples, to predict treatment responses induced by your target of interest, in skin and hair pathologies.
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We use state-of-the-art techniques and pre-clinical models, including organ culture of diseased skin samples to identify and establish biomarkers as early indicators for skin and hair disease progression.
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We offer pre-clinical models to test if the modulation of your target of interest efficiently affects skin and hair biology, ameliorates experimentally-induced pathological conditions or the phenotype of diseased samples.
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We offer pre-clinical models to investigate the localization and distribution of your compound/drug/nutraceutical in skin and hair samples to support the selection of best mode or vehicle for administration.
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We are happy to help you in customizing assays to optimally meet your research needs, and to join forces to establish clinically-meaningful models.
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We are constantly working on the establishment of new assays, in the context of our:
Advanced Technologies Program

We are experienced in customizing assays and establishing novel methods for our clients to optimize the scientific research output.
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